xkcd.WTF!?

Explanation ➲

This is another comic in a series related to the COVID-19 pandemic.

As with a number of previous strips, Randall has a tendency to anthropomorphize both pathogens and the immune system, envisioning the process of infection and immune response as an epic battle. In this case, he treats his immune system as he would a child trying to accomplish something difficult, and worries about its emotional reaction.

The COVID-19 vaccines (like all viral inoculations) work by introducing viral proteins into the body, causing the immune system to react as if the actual virus were present, creating the antibodies to fight it. As a result, if the actual virus is introduced, the immune system will have the capacity to quickly eliminate it.

In this comic, Cueball has just received the COVID-19 vaccine and anthropomorphizes this process. He worries that his immune system is "freaking out", as the vaccine causes the body to 'think' it's under attack and respond as it would to a deadly threat. Cueball accordingly tries to reassure his immune system that the threat isn't real. However, Megan reminds him that the "panic" is the entire point, as that's what causes the body to build defenses, which will allow it to handle the real virus. Cueball then switches tactics, melodramatically announcing that the virus is about to kill him, and encouraging his "heroic immune cells" to save the day. The joke is that the basic elements of their response is accurate: the vaccine is essentially a ruse intended to "trick" the immune system into developing antibodies. However, the immune system obviously lacks a separate consciousness, and can neither hear nor understand their comments,^{[citation needed]} making both reassurance and encouragement entirely moot.

In the title text, Cueball continues to treat his immune system like a conscious entity. Specifically, all of his communications sound like a parent, or other adult, trying to encourage a child who was trying to win a game: giving it a pep talk about how he doesn't care if it wins or loses as long as it has fun. This is a common refrain when parents or other adults try to reassure children in contexts where victory isn't especially important, and where enjoyment is the real goal. Cueball then remembers that this particular event is much more consequential. If his immune system were to 'lose' to the vaccine, that would presumably mean it was incapable of responding properly to the viral threat, meaning he'd be in serious risk of death if he contracted the actual virus. As a result, he corrects himself and states that winning, in this case, is "very important".