We've almost finished constructing the piña collider.
Scientists recreate conditions of things to gain scientific knowledge on a topic to better be able to observe why or how things happen. This could be done by making miniature versions of events and simulating events using safe methods.
In this comic, Megan's lab discovered that the conditions during the seconds after the Big Bang were extremely hot and unpleasant. They have thus decided to attempt to recreate the conditions of a tropical beach in 2014 instead (7 years prior to when this comic was released). Here, the joke is that instead of recreating a condition for scientific study purposes, Megan and her crew were simply trying to create a pleasant environment for recreation, in the sense of personal enjoyment.
The title text is a reference to 1949: Fruit Collider a pun of piña colada (Spanish for "strained Pineapple") and a particle collider: the Spanish word "colada" is pronounced similarly to the English word "collider". Taken literally, "piña collider" would be a pineapple collider, which may be interpreted as a fruit juicing machine for making piña coladas.