xkcd.WTF!?

Explanation ➲

Apparently, Randall hates some ridiculous neologisms. Cueball seems to be dictating a "Tween bromance" story or novel to Megan, who is possibly typing it up. He is including all the words that get to Megan in a sequence. Megan is just annoyed and starts to shriek in rage and annoyance; considering Cueball keeps speaking more annoying words in the title text, that seems to have been the point.

• "Tween" means a pre-adolescent. Portmanteau of teen and between, specifically above the age of 9 (the last value not in the tens) and below the age of 13 (the first actual "-teen" number).
• "Bromance" means a close non-sexual friendship between two males. Portmanteau of brother and romance.
• "Guesstimate" means an estimate made with very little information. Portmanteau of guess and estimate.
• "Frenemy" means a friend who is also a rival. Portmanteau of friend and enemy.
• "Yiff" is a word invented by the furry community. In most contexts it simply means "copulate", supposedly derived from the sound a fox makes during mating, and can refer to any form of sexual activity, including cybersex.
• "moist" is an ordinary word, but one that many people find mildly creepy, especially in this context.
• "Taint" is the part between the genitals and the anus (the perineum) in slang.
• "Panties" is a common term in the U.S. for women's underwear.
• "Preggers" a slang term for being pregnant.
• "verbiage" is a fairly new usage of an older word, meaning too many words used to explain a subject.
• "Va-jay-jay" /vəˈjājā/ IPA /vəˈdʒeɪdʒeɪ/ is a way of saying "vagina".
• "Irregardless" is a solecism. Or perhaps this portmanteau.

So, the full sentence roughly translates to: By my rough guess, my friend-slash-rival engaged in sexual activity so intensely that her wet perineum caused her underwear to become pregnant.

This is probably nonsensical, as clothing cannot bear children.^{[citation needed]} It may also reflect Cueball’s intentional parody of writers who lack understanding of anatomy/basic reasoning. However, at a stretch, the word “preggers” could be interpreted to refer to the rare, literal meaning of pregnant: full/filled. By this logic, “her moist taint made her panties preggers” would simply be an unusual way to say “her underwear were filled up with liquid”. But in that case: ew.

Like this comic fills a sentence with (gross) neologisms, 550: Density crams a sentence with memes.

According to 1485: Friendship, Randall doesn't like the word bromance much either. Uncomfortable synonyms are also seen in 1322: Winter and 2352: Synonym Date.