He holds the laptop like that on purpose, to make you cringe.
This comic is a good explanation of the correlation/causation fallacy, where one party states two unrelated events and posits that they must have influenced each other.
After hearing about the "Cell Phones Don't Cause Cancer" study, which refutes a claim made by the World Health Organization (just Google the debate or check out Wikipedia's article on it, the comic doesn't focus much on it), Black Hat plots "Total Cancer Incidence" per 100,000 and "Cell Phone Users" per 100 on the same graph. The graph in frame 3 shows an exponential rise in cancer in the 70's and 80's, followed by an exponential rise in cell phone usage in the 2000's. Black Hat reverses the correlation/causation fallacy, and comically comes to the conclusion that cancer causes cell phones.
The comic highlights a well-known fallacy known as post hoc ergo propter hoc, often shortened to simply post hoc. The Latin translates to "after this, therefore because of this,” (the simpler "after this" therefor implies “because of this”; post hoc, as it were!) referring to the common mistake that because two events happen in chronological order, the former event must have caused the latter event. The fallacy is often the root cause of many superstitions (e.g., a person noticing they wore a special bracelet before getting a good test score thinking the bracelet was the source of their good fortune), but it often crosses into more serious areas of thinking. In this case, the scientific research community, which often prides itself on its intellectual aptitude, is gently mocked for being nonetheless prone to such poor reasoning all too often. The different possibilities are generally known as causation, when one thing is proven to cause another, or correlation, when changes in one thing are aligned with changes in another, but there is no proof that they are directly related.
The title text refers to the way Black Hat holds the laptop in panel 2. Being that Cueball (and Randall, for that matter) are quite into computers, the potential damage to a laptop screen either from the weight of its lower body or the pressure of the user's fingers on the LCD screen is enough to make him squirm in discomfort. The risk of dropping the computer is also present. Both the fallacy and the way Black Hat is holding his laptop contribute to the "problems" that Cueball mentions.