'The Return of the Boomerang' would make a great movie title.
The comic appears to be a reference to 475: Further Boomerang Difficulties, which was a sequel to 445: I Am Not Good with Boomerangs, which had a man throwing a boomerang that never returned. Cueball shoots an arrow off with a bow and a boomerang returns to him. This confounds him. As it was also a Cueball that threw the boomerang in the other comic, this may be the same Cueball that now finally has his boomerang return to him after a long time (464 comics and nearly three years later). This would really freak him out then.
The title text is a pun on how boomerangs always come back, along with how "The Return of X" is often used for movie names.
However, as shown in the prequel as well as in an even earlier comic, Cueball/Randall has to admit: I Am Not Good with Boomerangs. So for him it would be a surprise if the boomerang returned!
Boomerangs also became a main theme in the interactive comic 1350: Lorenz.